Journal article
Contribution of Human papillomavirus in neuroendocrine tumors from a series of 10,575 invasive cervical cancer cases
M Alejo, L Alemany, O Clavero, B Quiros, S Vighi, M Seoud, C Cheng-Yang, SM Garland, N Juanpere, J Lloreta, S Tous, JE Klaustermeier, W Quint, FX Bosch, S de Sanjosé, B Lloveras
Papillomavirus Research | ELSEVIER | Published : 2018
Abstract
Aims: Neuroendocrine tumors (NET) of the cervix are rare tumors with a very aggressive course. The human papillomavirus (HPV) has been linked to its etiology. The objective of this study is to describe HPV prevalence and genotype distribution of NET. Methods and Results: Forty-nine tumors with histological neuroendocrine features were identified among 10,575 invasive cervical cancer (ICC) cases from an international study. HPV DNA detection was done using SPF10/DEIA /LiPA 25 system. Immunohistochemical (IHC) staining for neuroendocrine markers (chromogranin A, synaptophysin, CD56) and for p16 INK4a as a surrogate for HPV transforming infection was performed. In 13 samples with negative IHC f..
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Awarded by Merck
Funding Acknowledgements
This work was partially supported by public grants from the Instituto de Salud Carlos III (Spanish Government) (grant references: FIS PI030240, FIS PI061246, RCESP C03/09, RTICESP C03/10, RTIC RD06/0020/0095, RD12/0036/0056 and CIBERESP), from the Agencia de Gestio d'Ajuts Universitaris i de Recerca (Generalitat de Catalunya) (grant references: AGAUR 2005SGR 00695 and AGAUR 2009SGR126), and by research grants from the Marato de TV3 Foundation (grant reference: 051530), GlaxoSmithKline Biologicals, Sanofi Pasteur MSD and Merck & Co, Inc., who had no role in the data collection, analysis or interpretation of the results.