Higher parental occupational social contact is associated with a reduced risk of incident pediatric type 1 diabetes: Mediation through molecular enteroviral indices
Anne-Louise Ponsonby, Angela Pezic, Fergus J Cameron, Christine Rodda, Andrew S Kemp, John B Carlin, Heikki Hyoty, Amirbabak Sioofy-Khojine, Terence Dwyer, Justine A Ellis, Maria E Craig
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2018
We aimed to examine the association between parental occupational social contact and hygiene factors on type 1 diabetes (T1D) risk and possible mediation of these effects through child enteroviral infection. We interviewed 333 incident T1D cases and 660 controls from 2008-2011 in Melbourne, Australia. Enteroviral indices (ribonucleic acid by reverse transcription polymerase chain reaction and Coxsackie B virus antibody levels) in peripheral blood were measured in nested case control samples. Parent occupational social contact was assessed by the number of well or sick children, adults or animals contacted daily through work. Higher parental occupational social contact was strongly associated..View full abstract
Funding was obtained from the National Health and Medical Research Council of Australia, the Australian Research Council, Arthritis Australia, Diabetes Australia, Rebecca L Cooper Medical Research Foundation, L.E.W. Carty Charitable Fund, ANZ Medical Research and Technologies in Victoria Fund, Equity Trustees Lynne Quayle Charitable Trust Fund, the Australian Academy of Science, The Victorian State Government Operational Infrastructure Support Program, and the Murdoch Childrens Research Institute Internal Grant Scheme. JAE was supported by an Australian Research Council Future Fellowship. ALP was supported by a National Health and Medical Research Council Senior Research Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.