Journal article
Recipient mucosal-associated invariant T cells control GVHD within the colon
A Varelias, MD Bunting, KL Ormerod, M Koyama, SD Olver, J Straube, RD Kuns, RJ Robb, AS Henden, L Cooper, N Lachner, KH Gartlan, O Lantz, L Kjer-Nielsen, JYW Mak, DP Fairlie, AD Clouston, J McCluskey, J Rossjohn, SW Lane Show all
Journal of Clinical Investigation | AMER SOC CLINICAL INVESTIGATION INC | Published : 2018
DOI: 10.1172/JCI91646
Abstract
Mucosal-associated invariant T (MAIT) cells are a unique innate-like T cell subset that responds to a wide array of bacteria and yeast through recognition of riboflavin metabolites presented by the MHC class I-like molecule MR1. Here, we demonstrate using MR1 tetramers that recipient MAIT cells are present in small but definable numbers in graft-versus-host disease (GVHD) target organs and protect from acute GVHD in the colon following bone marrow transplantation (BMT). Consistent with their preferential juxtaposition to microbial signals in the colon, recipient MAIT cells generate large amounts of IL-17A, promote gastrointestinal tract integrity, and limit the donor alloantigen presentation..
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Funding Acknowledgements
This study was supported by an Australian National Health and Medical Research Council (NH&MRC) program grant held by GRH and PH; and a Cancer Council Queensland project grant held by AV, PH, GRH and KLO. We are grateful to Futoshi Kawamata, Paul Collins, Stephen Kazakoff, and Nic Waddell at QIMR Berghofer Medical Research Institute for assistance with RNA-seq. We thank Kelly Locke, Derek Weinert, and Luke Samson at QIMR Berghofer Medical Research Institute for technical assistance. We gratefully acknowledge Nicola Angel and Serene Low from the Australian Centre for Ecogenomics for assistance with sample preparation and 16S rRNA sequencing.