Journal article
Viral control in chronic HIV-1 subtype C infection is associated with enrichment of p24 IgG1 with Fc effector activity
AW Chung, JM Mabuka, B Ndlovu, A Licht, H Robinson, Y Ramlakhan, M Ghebremichael, T Reddy, PJR Goulder, BD Walker, T Ndungu, G Alter
AIDS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018
Abstract
Objective: Postinfection HIV viral control and immune correlates analysis of the RV144 vaccine trial indicate a potentially critical role for Fc receptor-mediated antibody functions. However, the influence of functional antibodies in clade C infection is largely unknown. Design: Plasma samples from 361 chronic subtype C-infected, antiretroviral therapy-naive participants were tested for their HIV-specific isotype and subclass distributions, along with their Fc receptor-mediated functional potential. Method: Total IgG, IgG subclasses and IgA binding to p24 clade B/C and gp120 consensus C proteins were assayed by multiplex. Antibody-dependent uptake of antigen-coated beads and Fc receptor-medi..
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Awarded by Howard Hughes Medical Institute
Funding Acknowledgements
We thank the study participants, the clinical and laboratory staff of the HIV Pathogenesis Programme. This work was supported by the National Institute of Health (R01 AI080289 and R01 A102660-01), the Bill and Melinda Gates Foundation CAVD (OPP1032817: Leveraging Antibody Effector Function), the Ragon Institute of MGH, MIT and Harvard, the South African Research Chairs Initiative, the Victor Daitz Foundation and an International Early Career Scientist Award from the Howard Hughes Medical Institute to T.N., National Health and Medical Research Council and the American Foundation for AIDS Research Mathilde Krim Fellowship to A.W.C.