Journal article
Distinct child-to-adult body mass index trajectories are associated with different levels of adult cardiometabolic risk
MJ Buscot, RJ Thomson, M Juonala, MA Sabin, DP Burgner, T Lehtimäki, N Hutri-Kähönen, JSA Viikari, OT Raitakari, CG Magnussen
European Heart Journal | OXFORD UNIV PRESS | Published : 2018
Abstract
Aims The relationship between life-course body mass index (BMI) trajectories and adult risk for cardiovascular disease (CVD) is poorly described. In a longitudinal cohort, we describe BMI trajectories from early childhood to adulthood and investigate their association with CVD risk factors [Type 2 diabetes mellitus (T2DM), high-risk lipid levels, hypertension, and high carotid intima-media thickness (cIMT)] in adulthood (34–49 years). Methods Six discrete long-term BMI trajectories were identified using latent class growth mixture modelling among 2631 and results Cardiovascular Risk in Young Finns Study participants (6–49 years): stable normal (55.2%), resolving (1.6%), progressively overwei..
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Awarded by Tampereen Tuberkuloosisäätiö
Funding Acknowledgements
The YFS has been financially supported by the Academy of Finland [286284, 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi), and 41071 (Skidi)]; the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals (grant X51001); Juho Vainio Foundation; Paavo Nurmi Foundation; Finnish Foundation for Cardiovascular Research; Finnish Cultural Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation; Yrjo Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Diabetes Research Foundation of Finnish Diabetes Association, Sigrid Juselius Foundation, Maud Kuistila Foundation, the Finnish Medical Foundation, and the Orion-Farmos Research Foundation. This work was partly funded by the National Health and Medical Research Council (NHMRC) Project Grant (APP1098369). D.P.B. is supported by an NHMRC Senior Research Fellowship (APP1064629). C.G.M. is supported by a National Heart Foundation of Australia Future Leader Fellowship (100849).