Journal article

Incidence and prevalence of bacteriologically confirmed pulmonary tuberculosis among adolescents and young adults: a systematic review

Kathryn J Snow, Lisa J Nelson, Charalambos Sismanidis, Susan M Sawyer, Stephen M Graham

EPIDEMIOLOGY AND INFECTION | CAMBRIDGE UNIV PRESS | Published : 2018

Abstract

The burden of tuberculosis (TB) among adolescents and young adults in endemic settings is poorly characterised. This study aimed to review published and unpublished estimates of the incidence and prevalence of bacteriologically confirmed TB among young people aged 10-24 years. We searched PubMed and World Health Organization archives for publications and unpublished data from population-based epidemiologic studies reporting confirmed pulmonary TB among young people, conducted from January 2000 onwards. We identified 27 publications and unpublished data from two national surveys, representing a total of 26 studies in 19 countries. The prevalence of bacteriologically confirmed TB ranged from 4..

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Grants

Funding Acknowledgements

Nathan Ford and Amitabh Suthar (World Health Organization) provided early guidance on the search strategy. Irwin Law and Ikushi Onozaki (World Health Organization (WHO)) provided valuable guidance on the design and analysis of national prevalence surveys, and Irwin Law kindly assisted in locating relevant published and unpublished data in WHO records. Ben Marais responded to a request for additional adolescent data from his study in South Africa. Rashida Ferrand provided insight into diagnostic issues among children and adolescents living with HIV. This work was funded by the NHMRC Centre for Research Excellence in Tuberculosis (TBCRE) seed funding scheme. The funder did not have any role in the design or conduct of the research. CS is a staff member of the WHO. The author alone is responsible for the views expressed in this publication and they do not necessarily represent the decisions or policies of the WHO.