Journal article
Oncogenic Signaling Pathways in The Cancer Genome Atlas
F Sanchez-Vega, M Mina, J Armenia, WK Chatila, A Luna, KC La, S Dimitriadoy, DL Liu, HS Kantheti, S Saghafinia, D Chakravarty, F Daian, Q Gao, MH Bailey, WW Liang, SM Foltz, I Shmulevich, L Ding, Z Heins, A Ochoa Show all
Cell | Published : 2018
Abstract
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFβ signaling, p53 and β-catenin/Wnt. We charted the detailed landscape of pathway alterations in 33 cancer types, stratified into ..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by NIH Grants U54 HG003273, U54 HG003067, U54 HG003079, U24 CA143799, U24 CA143835, U24 CA143840, U24 CA143843, U24 CA143845, U24 CA143848, U24 CA143858, U24 CA143866, U24 CA143867, U24 CA143882, U24 CA143883, U24 CA144025, P30 CA016672.