Mucin gel assembly is controlled by a collective action of non-mucin proteins, disulfide bridges, Ca2 -mediated links, and hydrogen bonding
Oliver W Meldrum, Gleb E Yakubov, Mauricio R Bonilla, Omkar Deshmukh, Michael A McGuckin, Michael J Gidley
Scientific Reports | NATURE PUBLISHING GROUP | Published : 2018
Awarded by Australian Research Council (ARC) through the ARC Centre of Excellence in Plant Cell Walls
Awarded by ARC Discovery Project
The authors would like to gratefully acknowledge Prof. Jason Stokes (University of Queensland) for access to rheometer facilities as well as many in-depth discussions regarding rheological properties and techniques. We also acknowledge Prof. Tom Waigh (University of Manchester) and Dr. Heather Davies (University of Manchester) for helpful discussion. The University of Queensland Piggery is acknowledged for their support with mucus collection. Dr. Amanda Nouwens from the Proteomics Analysis and Biological Mass Spectrometry Facility (University of Queensland) is acknowledged for conducting proteomic analysis. This work was performed in part at the Queensland node of the Australian National Fabrication Facility (ANFF-Q), a company established under the National Collaborative Research Infrastructure Strategy to provide nano- and microfabrication facilities for Australia's researchers. This work was supported by the Australian Research Council (ARC) through the ARC Centre of Excellence in Plant Cell Walls (CE110001007), the ARC Discovery Project DP150104147, and an Australian Postgraduate Award scholarship to OWM. MAM is supported by a NHMRC Principal Research Fellowship. The Translational Research Institute is supported by a grant from the Australian Government.