The transgenerational effect of maternal and paternal F1 low birth weight on bone health of second and third generation offspring
K Anevska, JD Wark, ME Wlodek, T Romano
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE | CAMBRIDGE UNIV PRESS | Published : 2019
Low birth weight programs diseases in adulthood, including adverse bone health. These diseases can have intergenerational and transgenerational origins, whereby transmission to subsequent generations occurs via both parental lines. Uteroplacental insufficiency surgery (Restricted) or sham surgery (Control) was performed on gestational day 18, in F0 Wistar-Kyoto rats. F1 Restricted males and females mated with breeders in order to generate F2 offspring of maternal and paternal lineages. F2 males and females were randomly selected for breeding to generate F3 offspring. F2 and F3 offspring did not have differences in birth weight irrespective of F1 low birth weight and parental line. Maternal l..View full abstract
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Awarded by National Health and Medical Research Council of Australia
M.E.W. received funding from the National Health and Medical Research Council of Australia (APP1025426; APP1045602). K.A. is supported by an Australian Government Research Training Program Scholarship.