Journal article

A Low Glycaemic Index Diet in Pregnancy Induces DNA Methylation Variation in Blood of Newborns: Results from the ROLO Randomised Controlled Trial

Aisling A Geraghty, Alexandra Sexton-Oates, Eileen C O'Brien, Goiuri Alberdi, Peter Fransquet, Richard Saffery, Fionnuala M McAuliffe

NUTRIENTS | MDPI | Published : 2018

Abstract

The epigenetic profile of the developing fetus is sensitive to environmental influence. Maternal diet has been shown to influence DNA methylation patterns in offspring, but research in humans is limited. We investigated the impact of a low glycaemic index dietary intervention during pregnancy on offspring DNA methylation patterns using a genome-wide methylation approach. Sixty neonates were selected from the ROLO (Randomised cOntrol trial of LOw glycaemic index diet to prevent macrosomia) study: 30 neonates from the low glycaemic index intervention arm and 30 from the control, whose mothers received no specific dietary advice. DNA methylation was investigated in 771,484 CpG sites in free DNA..

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Grants

Awarded by European Union's Seventh Framework Programme (FP7/2007-2013), project EarlyNutrition


Funding Acknowledgements

The authors would like to thank all the participants from the ROLO Study. This study was supported by the Health Research Board Ireland, Health Research Centre for Health and Diet Research, The National Maternity Hospital Medical Fund, and the European Union's Seventh Framework Programme (FP7/2007-2013), project EarlyNutrition under grant agreement No. 289346. Richard Saffery is supported by a National Health and Medical Research Council (Australia) Senior Research Fellowship and the Victorian Government Operational Infrastructure support scheme. The funders had no role in the design of the study and collection, analysis, and interpretation of data or in writing the manuscript.