Journal article

Nonconvulsive status epilepticus in rats leads to brain pathology

Una Avdic, Matilda Ahl, Deepti Chugh, Idrish Ali, Karthik Chary, Alejandra Sierra, Christine T Ekdahl

EPILEPSIA | WILEY | Published : 2018

Abstract

OBJECTIVE: Status epilepticus (SE) is an abnormally prolonged epileptic seizure that if associated with convulsive motor symptoms is potentially life threatening for a patient. However, 20%-40% of patients with SE lack convulsive events and instead present with more subtle semiology such as altered consciousness and less motor activity. Today, there is no general consensus regarding to what extent nonconvulsive SE (NCSE) is harmful to the brain, which adds uncertainty to stringent treatment regimes. METHODS: Here, we evaluated brain pathology in an experimental rat and mouse model of complex partial NCSE originating in the temporal lobes with Western blot analysis, immunohistochemistry, and ..

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