A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

AC Berger; A Korkut; RS Kanchi; AM Hegde; W Lenoir; W Liu; Y Liu; H Fan; H Shen; V Ravikumar; A Rao; A Schultz; X Li; P Sumazin; C Williams; P Mestdagh; PH Gunaratne; C Yau; R Bowlby; AG Robertson; DG Tiezzi; C Wang; AD Cherniack; AK Godwin; NM Kuderer; JS Rader; RE Zuna; AK Sood; AJ Lazar; AI Ojesina; C Adebamowo; SN Adebamowo; KA Baggerly; TW Chen; HS Chiu; S Lefever; L Liu; K MacKenzie; S Orsulic; J Roszik; CS Shelley; Q Song; CP Vellano; N Wentzensen; SJ Caesar-Johnson; JA Demchok; I Felau; M Kasapi; ML Ferguson; CM Hutter; HJ Sofia; R Tarnuzzer; Z Wang; L Yang; JC Zenklusen; J Zhang; S Chudamani; J Liu; L Lolla; R Naresh; T Pihl; Q Sun; Y Wan; Y Wu; J Cho; T DeFreitas; S Frazer; N Gehlenborg; G Getz; DI Heiman; J Kim; MS Lawrence; P Lin; S Meier; MS Noble; G Saksena; D Voet; H Zhang; B Bernard; N Chambwe; V Dhankani; T Knijnenburg; R Kramer; K Leinonen; M Miller; S Reynolds; I Shmulevich; V Thorsson; W Zhang; R Akbani; BM Broom; Z Ju; J Li; H Liang; S Ling; Y Lu; GB Mills; KS Ng; M Ryan; J Wang

Journal article

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

AC Berger, A Korkut, RS Kanchi, AM Hegde, W Lenoir, W Liu, Y Liu, H Fan, H Shen, V Ravikumar, A Rao, A Schultz, X Li, P Sumazin, C Williams, P Mestdagh, PH Gunaratne, C Yau, R Bowlby, AG Robertson Show all

Cancer Cell | Published : 2018

DOI: 10.1016/j.ccell.2018.03.014

Abstract

We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations (SCNAs) and 46 significantly mutated genes (SMGs). Eleven SCNAs and 11 SMGs had not been identified in previous TCGA studies of the individual tumor types. We found functionally significant estrogen receptor-regulated long non-coding RNAs (lncRNAs) and gene/lncRNA interaction networks. Pathway analysis identified subtypes with high leukocyte infiltration, raising potential implications for immunothera..

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University of Melbourne Researchers

Christopher Hovens Author

Anthony Costello Author

Michael Lawrence Author

Alex Boussioutas Author

Grants

Awarded by National Human Genome Research Institute

Funding Acknowledgements

This work was supported by the following NCI grants: U54 HG003273, U54 HG003067, U54 HG003079, U24 CA143799, U24 CA143835, U24 CA143840, U24 CA143843, U24 CA143845, U24 CA143848, U24 CA143858, U24 CA143866, U24 CA143867, U24 CA143882, U24 CA143883, U24 CA144025, U24 CA210949, U24 CA210950, P30 CA016672, P50 CA136393.