Journal article
The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
Christopher J Ricketts, Aguirre A de Cubas, Huihui Fan, Christof C Smith, Martin Lang, Ed Reznik, Reanne Bowlby, Ewan A Gibb, Rehan Akbani, Rameen Beroukhim, Donald P Bottaro, Toni K Choueiri, Richard A Gibbs, Andrew K Godwin, Scott Haake, A Ari Hakimi, Elizabeth P Henske, James J Hsieh, Thai H Ho, Rupa S Kanchi Show all
CELL REPORTS | CELL PRESS | Published : 2018
Abstract
Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased ..
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Awarded by NIH Genome sequencing center
Awarded by NIH Genome data analysis center and genome characterization center
Awarded by NIH PCC grant
Awarded by Frederick National Laboratory for Cancer Research, NIH
Awarded by NATIONAL CANCER INSTITUTE
Awarded by NATIONAL HUMAN GENOME RESEARCH INSTITUTE
Funding Acknowledgements
This study was performed using the following grants: NIH Genome sequencing center grants U54 HG003273 for R.A.G., U54 HG003067 for S. Gabriel and E.S. Lander, and U54 HG003079 for R.K. Wilson; NIH Genome data analysis center and genome characterization center grants U24 CA143799 for T.P. Speed and P.T.S., U24 CA143835 for I. Shmulevich, U24 CA143840 for M. Ladanyi and C. Sander, U24 CA143843 for R.A.G. and D.A.W., U24 CA143845 for G. Getz and L. Chin, U24 CA143848 for D.N. Hayes and C.M. Perou, U24 CA143858 for J. Stuart, C. Benz, and D.H. Haussler, U24 CA143866 for M. A. Marra, U24 CA143867 for S. Gabriel and M. L. Meyerson, U24 CA143882 for S. B. Baylin and P.W. Laird, U24 CA143883 for G. B. M., R.A., W.K.A. Yung, and J.N. Weinstein, and U24 CA144025 for R.S. Kucherlapati; and NIH PCC grant P30 CA016672 for G. B. M. This project has been funded in part with federal funds from the Frederick National Laboratory for Cancer Research, NIH, under contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.