Journal article
Rapid loss of group 1 innate lymphoid cells during blood stage Plasmodium infection
SS Ng, F Souza-Fonseca-Guimaraes, FDL Rivera, FH Amante, R Kumar, Y Gao, M Sheel, L Beattie, M Montes De Oca, C Guillerey, CL Edwards, RJ Faleiro, T Frame, PT Bunn, E Vivier, DI Godfrey, DG Pellicci, JA Lopez, KT Andrews, ND Huntington Show all
Clinical and Translational Immunology | WILEY | Published : 2018
DOI: 10.1002/cti2.1003
Abstract
Objectives: Innate lymphoid cells (ILCs) share many characteristics with CD4+ T cells, and group 1 ILCs share a requirement for T-bet and the ability to produce IFNγ with T helper 1 (Th1) cells. Given this similarity, and the importance of Th1 cells for protection against intracellular protozoan parasites, we aimed to characterise the role of group 1 ILCs during Plasmodium infection. Methods: We quantified group 1 ILCs in peripheral blood collected from subjects infected with with Plasmodium falciparum 3D7 as part of a controlled human malaria infection study, and in the liver and spleens of PcAS-infected mice. We used genetically-modified mouse models, as well as cell-depletion methods in m..
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Awarded by Australian Research Council
Funding Acknowledgements
This work was made possible through Queensland State Government funding. The research was supported by grants and fellowships from the National Health and Medical Research Council of Australia (NHMRC) and Australia Research Council (ARC), as well as Australian Postgraduate Awards through Griffith University, School of Natural Sciences and the University of Queensland, School of Medicine and an INSPIRE Fellowship to Rajiv Kumar provided by the Indian government Department of Science and Technology. Funding for the CHMI studies was provided by Medicines for Malaria Venture (MMV) from grants awarded by the Wellcome Trust and Bill and Melinda Gates Foundation