Journal article
Rifampicin resistance in Staphylococcus epidermidis: molecular characterisation and fitness cost of rpoB mutations
YM Wi, KE Greenwood-Quaintance, CL Brinkman, JYH Lee, BP Howden, R Patel
International Journal of Antimicrobial Agents | ELSEVIER SCIENCE BV | Published : 2018
Abstract
The molecular mechanisms and characteristics of rifampicin (RIF) resistance in Staphylococcus epidermidis are poorly characterised, even though S. epidermidis is one of the most common nosocomial pathogens associated with indwelling medical device-related infections. The aim of this study was to investigate the evolution of RIF resistance and to characterise the associated molecular mechanisms in S. epidermidis. RIF-resistant mutants from two RIF-susceptible S. epidermidis strains (RP62A and IDRL-8883) were selected through in vitro and in vivo exposure to RIF. A total of 16 colonies with an RP62A background and 63 colonies with an IDRL-8883 background were analysed for rpoB mutations. The f..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This work was supported by the National Institute of Allergy and Infectious Diseases [grant no. R21 AI125870]. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.