Journal article

Utility of Using the Montreal Cognitive Assessment (MoCA) as a Screening Tool for HIV-Associated Neurocognitive Disorders (HAND) In Multi-Ethnic Malaysia

Trena Mukherjee, Rishanantini Sakthivel, Ho Yen Fong, Megan McStea, Meng Li Chong, Sharifah Faridah Omar, Ai Vyrn Chin, Shahrul Kamaruzzaman, Adeeba Kamarulzaman, Reena Rajasuriar, Lucette A Cysique

AIDS AND BEHAVIOR | SPRINGER/PLENUM PUBLISHERS | Published : 2018

Abstract

This study determines the optimal cut-off scores for the Montreal Cognitive Assessment (MoCA) to detect HIV-associated neurocognitive disorders (HAND) in a multi-ethnic Malaysian HIV-positive cohort by developing demographically corrected normative standards among 283 HIV-negative community-based controls with overlapping demographic characteristics. The norms (corrected for age, sex, education, ethnicity) were applied to 342 HIV-positive virally suppressed individuals on cART. Impairment rates were classified using the Global Deficit Score (GDS ≥ .5) method. The MoCA was also scored according to the recommended cut-off of ≤ 26, and functional decline was applied to both impairment definitio..

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University of Melbourne Researchers

Grants

Awarded by University of Malaya High Impact Research grant


Awarded by National Institute of Allergy & Infectious Diseases of the National Institutes of Health


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This study was funded by the University of Malaya High Impact Research grants HIR/MOHE H-20001-E000001 (RR, AK, SFO), UM.0000099/HIR.C3 (SK, AVC) and by the National Institute of Allergy & Infectious Diseases of the National Institutes of Health under award number T32AI114398 (TM). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.