Journal article
Design and methods of the REMOVAL-HD study: A tRial Evaluating Mid cut-Off Value membrane clearance of Albumin and Light chains in HaemoDialysis patients
R Krishnasamy, CM Hawley, MJ Jardine, MA Roberts, YJ Cho, MG Wong, A Heath, CL Nelson, S Sen, PF Mount, EM Pascoe, D Darssan, LA Vergara, PA Paul-Brent, ND Toussaint, DW Johnson, CA Hutchison
BMC Nephrology | BMC | Published : 2018
Abstract
Background: Removal of uraemic toxins is inadequate using current dialysis strategies. A new class of dialysis membranes have been developed that allow clearance of larger middle molecules. The REMOVAL-HD study (a tRial Evaluating Mid cut-Off Value membrane clearance of Albumin and Light chains in HaemoDialysis patients) will address safety, efficacy and the impact on patient-centred outcomes with the use of a mid cut-off (MCO) dialyser in a chronic haemodialysis (HD) population. Methods: REMOVAL-HD is an open label, prospective, non-randomised, single-arm, multi-centre device study in 85 chronic HD participants. All visits will be conducted during regular HD sessions and participants will u..
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Funding Acknowledgements
Baxter Investigator Initiated Research (IIR) Grant and Kidney Health Australia via the AKTN. This is an investigator initiated study and Baxter had no role in study design, conduct, data collection, analysis and preparation of this manuscript.