Association between measures of treatment quality and disease progression in prostate cancer radiotherapy: An exploratory analysis from the TROG 03.04 RADAR trial
Marco Marcello, Martin A Ebert, Annette Haworth, Allison Steigler, Angel Kennedy, Max Bulsara, Rachel Kearvell, David J Joseph, James W Denham
Journal of Medical Imaging and Radiation Oncology | WILEY | Published : 2018
INTRODUCTION: Quality assurance methods are incorporated into multicentre radiotherapy clinical trials for ensuring consistent application of trial protocol and quantifying treatment uncertainties. The study's purpose was to determine whether post-treatment disease progression is associated with measures of the quality of radiotherapy treatment. METHODS: The TROG 03.04 RADAR trial tested the impact of androgen deprivation on prostate cancer patients receiving dose-escalated external beam radiation therapy. The trial incorporated a plan-review process and Level III dosimetric intercomparison at each centre, from which variables suggestive of treatment quality were collected. Kaplan-Meier stat..View full abstract
Awarded by Australian National Health and Medical Research Council
We acknowledge funding from the Australian National Health and Medical Research Council (grants 300705, 455521, 1006447, 1077788), the Hunter Medical Research Institute, the Health Research Council (New Zealand), the University of Newcastle, the Calvary Mater Newcastle, Abbott Laboratories and Novartis Pharmaceuticals. We gratefully acknowledge the support of the Sir Charles Gairdner Hospital, the 'Elvis' study team including Kristie Harrison, participating RADAR centres, the Trans-Tasman Radiation Oncology Group, BenHooton and Elizabeth van der Wath.