Dissociations of the Fluocinolone Acetonide Implant: The Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study

JT Holbrook; EA Sugar; AE Burke; AT Vitale; JE Thorne; JL Davis; DA Jabs; GJ Jaffe; B Branchaud; P Hahn; L Koreen; EM Lad; P Lin; JN Martel; N (Shah) Serrano; C Skalak; L Vajzovic; C Baer; J Bryant; S Chavala; M Cusick; S Day; P Dayani; J Ehlers; M Kesen; A Lee; A Melamud; JA Qureshi; AW Scott; RF See; RK Shuler; M Wood; S Yeh; A Fernandes; D Gibbs; D Leef; DF Martin; S Srivastava; JP Dunn; H Begum; JA Boring; KL Brotherson; B Burkholder; NJ Butler; D Cain; MA Cook; D Emmert; JR Graul; M Herring; A Laing; TG Leung; MC Mahon; A Moradi; A Nwankwo; TL Ostheimer; T Reed; E Arnold; PM Barnabie; ML Belair; SG Bolton; JB Brodine; DM Brown; LM Brune; A Galor; T Gan; A Jacobowitz; M Kapoor; S Kedhar; S Kim; HA Leder; AG Livingston; Y Morton; K Nolan; GB Peters; P Soto; R Stevenson; M Tarver-Carr; Y Wang; CS Foster; SD Anesi; Linda Bruner; O Ceron; DM Hinkle; N Persons; B Wentworth; S Acevedo; F Anzaar; T Cesca; A Contero; K Fitzpatrick; F Goronga; J Johnson; KQ Lebron; D Marvell; C Morgan; N Patel; J Pinto; SS Siddique; J Sprague; T Yilmaz

Journal article

Dissociations of the Fluocinolone Acetonide Implant: The Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study

JT Holbrook, EA Sugar, AE Burke, AT Vitale, JE Thorne, JL Davis, DA Jabs, GJ Jaffe, B Branchaud, P Hahn, L Koreen, EM Lad, P Lin, JN Martel, N (Shah) Serrano, C Skalak, L Vajzovic, C Baer, J Bryant, S Chavala Show all

American Journal of Ophthalmology | ELSEVIER SCIENCE INC | Published : 2016

DOI: 10.1016/j.ajo.2015.12.028

Abstract

Purpose: To describe fluocinolone acetonide implant dissociations in the Multicenter Uveitis Steroid Treatment (MUST) Trial. Design: Randomized clinical trial with extended follow-up. Methods: Review of data collected on the first implant in the eye(s) of participants. Dissociation was defined as the drug pellet no longer being affixed to the strut and categorized as spontaneous or surgically related. Results: A total of 250 eyes (146 patients) had at least 1 implant placed. Median follow-up time after implant placement was 6 years (range 0.5–9.2 years). Thirty-four dissociations were reported in 30 participants. There were 22 spontaneous events in 22 participants; 6-year cumulative risk of ..

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University of Melbourne Researchers

Ehud Zamir Author

Lyndell Lim Author

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

SUPPORTED BY COLLABORATIVE AGREEMENTS U10 EY 014655 TO THE ICAHN SCHOOL OF MEDICINE AT Mount Sinai, New York, New York (Douglas A. Jabs), U10 EY 014660 to the Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland (Janet T. Holbrook), and U10 EY 014656 to the University of Wisconsin, Madison, School of Medicine and Public Health, Madison Wisconsin (Dr. Michael M. Altaweel) from the National Eye Institute, National Institutes of Health, Bethesda, Maryland. Bausch and Lomb, Inc (Bridgewater, New Jersey) provided a limited number of fluocinolone acetonide implants to the trial for use at centers without access to implants.