Conference Proceedings
Cognitive functioning following discontinuation of antipsychotic medication. A naturalistic sub-group analysis from the OPUS II trial
N Albert, L Randers, K Allott, HD Jensen, M Melau, C Hjorthoj, M Nordentoft
Psychological Medicine | CAMBRIDGE UNIV PRESS | Published : 2019
Abstract
Background The effect of antipsychotics medication on cognitive functioning in patients diagnosed with schizophrenia is poorly understood. Some studies of second generation antipsychotics indicated that they improved cognitive functioning while other studies have found that they decrease the level of cognitive functioning.Method We included patients with schizophrenia who were in treatment with antipsychotics 1.5 years (baseline) after initiation of treatment and followed them up 3.5 years later (n = 189). At follow-up 60 (32%) had discontinued their antipsychotic treatment and 129 (68%) were still taking antipsychotics. Using the Brief Assessment of Cognition in Schizophrenia (BACS) we asse..
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Awarded by University of Melbourne
Funding Acknowledgements
This study was funded by The Danish Agency for Science and Technology and Innovation (271-08-0568) and the TrygFonden (7-10-1057). The Capital Region Denmark and The Central Region Denmark funded the clinical part of the trial. KA is supported by a Ronald Philip Griffiths Fellowship, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne. The funding sources had no part in the planning of the study, collecting or analyses of the data, interpreting the results, writing the manuscript or decision to submit the manuscript.