Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms
Thomas A Forbes, Sara E Howden, Kynan Lawlor, Belinda Phipson, Jovana Maksimovic, Lorna Hale, Sean Wilson, Catherine Quinlan, Gladys Ho, Katherine Holman, Bruce Bennetts, Joanna Crawford, Peter Trnka, Alicia Oshlack, Chirag Patel, Andrew Mallett, Cas Simons, Melissa H Little
The American Journal of Human Genetics | CELL PRESS | Published : 2018
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by NHMRC Postgraduate Scholarship
We thank Pei Xuan Er and Irene Ghobrial for assistance with iPSC derivation and maintenance, Alison Graham for iPSC pluripotency flow cytometry, and Andrew Lonsdale for assistance with bioinformatic graphical outputs. This study was funded by the National Health and Medical Research Council of Australia (NHMRC) (GNT1098654), Kidney Health Australia, the Royal Brisbane and Women's Hospital Foundation, the Royal Children's Hospital Foundation, and the Murdoch Children's Research Institute. The Murdoch Childrens Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. T.A.F. is a recipient of the NHMRC Postgraduate Scholarship (GNT1114409) and RACP Jacquot Award. M.H.L. is an NHMRC Senior Principal Research Fellow and has consulted for and received research funding from Organovo Inc.