Journal article
Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy
CD Britto, ZA Dyson, S Duchene, MJ Carter, M Gurung, DF Kelly, DR Murdoch, I Ansari, S Thorson, S Shrestha, N Adhikari, G Dougan, KE Holt, AJ Pollard
Plos Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2018
Abstract
Background: Children are substantially affected by enteric fever in most settings with a high burden of the disease, including Nepal. However pathogen population structure and transmission dynamics are poorly delineated in young children, the proposed target group for immunization programs. Here we present whole genome sequencing and antimicrobial susceptibility data on 198 S. Typhi and 66 S. Paratyphi A isolated from children aged 2 months to 15 years of age during blood culture surveillance at Patan Hospital, Nepal, 2008–2016. Principal findings: S. Typhi was the dominant agent and comprised several distinct genotypes, dominated by 4.3.1 (H58). The heterogeneity of genotypes in children un..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
CDB is a Rhodes scholar, class of 2015 funded by the Rhodes trust. ZAD was supported by the Wellcome Trust of Great Britain (106158/Z/14/Z). SD was supported by a McKenzie Fellowship from the University of Melbourne. KEH was supported by the NHMRC of Australia (Fellowship #1061409). GD is supported by the NIHR Cambridge, BRC and the Wellcome trust. AJP is funded the NIHR Oxford, BRC and Wellcome trust. The authors also wish to acknowledge the Gates foundation, which support enteric fever studies conducted by our group in Nepal. The sequencing of isolates in this study was funded by the Wellcome Trust Strategic Award: "A strategic vision to drive the control of enteric fever through vaccination" Strategic Award (106158/Z/14/Z). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.