Journal article

The molecular signature of muscle stem cells is driven by nutrient availability and innate cell metabolism

James G Ryall, Gordon S Lynch

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2018

Abstract

PURPOSE OF REVIEW: To discuss how innate muscle stem-cell metabolism and nutrient availability can provide temporal regulation of chromatin accessibility and transcription. RECENT FINDINGS: Fluorescence-activated cell sorting coupled with whole transcriptome sequencing revealed for the first time that quiescent and proliferating skeletal muscle stem cells exhibit a process of metabolic reprogramming, from fatty-acid oxidation during quiescence to glycolysis during proliferation. Using a combination of immunofluorescence and chromatin immunoprecipitation sequencing, this shift in metabolism has been linked to altered availability of key metabolites essential for histone (de)acetylation and (d..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Australian Research Council


Funding Acknowledgements

J.G.R. and G.S.L. are supported by research grants from the National Health and Medical Research Council of Australia (GNT1120714) and the Australian Research Council (DP150100206).