The evolving role of lymphatics in cancer metastasis
Rae H Farnsworth, Marc G Achen, Steven A Stacker
CURRENT OPINION IN IMMUNOLOGY | CURRENT BIOLOGY LTD | Published : 2018
While the link between the lymphatic system and the metastatic spread of cancer is centuries old, understanding of the underlying mechanisms is still evolving. Lymphatic vessels provide a route for tumour cells to reach regional lymph nodes (LNs), which is prognostic of distant organ metastasis and poor survival. However, genomic analyses of metastatic cancer now reveal complex patterns of dissemination. The lymphatic endothelial cells lining lymphatics respond to molecular cues from the tumour microenvironment, mediating growth and remodelling of lymphatic vessels at the primary tumour, draining LNs and distant premetastatic niches. Recent studies emphasise that this not only supports metas..View full abstract
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Awarded by National Health and Medical Research Council of Australia
S.A.S. and M.G.A. have been supported by Program Grants (1053535), Project Grants (1045518; 1045523) and Senior Research Fellowships (542502; 1060498) from the National Health and Medical Research Council of Australia. We also thank Christopher Hovens for helpful discussions regarding the role of clonal evolution in the metastatic process. We apologise to authors whose relevant work could not be cited due to space restrictions, and refer readers to highlighted recent papers and reviews for further reading.