Modelling Cooperative Tumorigenesis in Drosophila
Helena E Richardson, Marta Portela
BIOMED RESEARCH INTERNATIONAL | HINDAWI LTD | Published : 2018
The development of human metastatic cancer is a multistep process, involving the acquisition of several genetic mutations, tumour heterogeneity, and interactions with the surrounding microenvironment. Due to the complexity of cancer development in mammals, simpler model organisms, such as the vinegar fly, Drosophila melanogaster, are being utilized to provide novel insights into the molecular mechanisms involved. In this review, we highlight recent advances in modelling tumorigenesis using the Drosophila model, focusing on the cooperation of oncogenes or tumour suppressors, and the interaction of mutant cells with the surrounding tissue in epithelial tumour initiation and progression.
Awarded by Spanish Ministerio de Ciencia e Innovacion (MICINN)
The authors thank John E. La Marca for comments on the manuscript. Helena E. Richardson is supported by funds from the La Trobe Institute of Molecular Science and La Trobe University, and Marta Portela was supported by Juan de la Cierva-Incorporacion postdoctoral fellowship (IJCI-2014-19272) from the Spanish Ministerio de Ciencia e Innovacion (MICINN). The authors apologize to the Drosophila community, if they have inadvertently missed any relevant literature in the writing of this review.