Journal article

Relationship between Epigenetic Maturity and Respiratory Morbidity in Preterm Infants

Anna K Knight, Alicia K Smith, Karen N Conneely, Philippa Dalach, Yuk J Loke, Jeanie L Cheong, Peter G Davis, Jeffrey M Craig, Lex W Doyle, Christiane Theda

The Journal of Pediatrics | MOSBY-ELSEVIER | Published : 2018

Abstract

OBJECTIVE: To assess associations between epigenetic maturity of extremely preterm babies (born at less than 28 weeks of gestation), neonatal interventions, and respiratory outcomes, including the administration of surfactant and postnatal corticosteroids, duration of assisted ventilation, and development of bronchopulmonary dysplasia (BPD). STUDY DESIGN: DNA was extracted from neonatal blood spots collected after birth from 143 extremely preterm infants born 1991-1992 in Victoria, Australia and used to determined DNA methylation (DNAm). A DNAm based gestational age was determined using our previously published method. The residual of DNAm gestational age and clinically estimated gestational..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Centre of Research Excellence


Awarded by Children's Foundation


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

Supported by the National Health and Medical Research Council (NHMRC) of Australia (APP1083779 [to J.M.C., C.T., and J.L.C.] and 491246 [to L.D. and J.L.C.); the Centre of Research Excellence (APP1060733 [to L.D., P.D., and J.L.C]); and further funded by the Children's Foundation (2014-134 [to J.M.C., L.D., and C.T.]). The Murdoch Childrens Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. The authors declare no conflicts of interest.