Journal article

Radial-Artery or Saphenous-Vein Grafts in Coronary-Artery Bypass Surgery

Mario Gaudino, Umberto Benedetto, Stephen Fremes, Giuseppe Biondi-Zoccai, Art Sedrakyan, John D Puskas, Gianni D Angelini, Brian Buxton, Giacomo Frati, David L Hare, Philip Hayward, Giuseppe Nasso, Neil Moat, Miodrag Peric, Kyung J Yoo, Giuseppe Speziale, Leonard N Girardi, David P Taggart



BACKGROUND: The use of radial-artery grafts for coronary-artery bypass grafting (CABG) may result in better postoperative outcomes than the use of saphenous-vein grafts. However, randomized, controlled trials comparing radial-artery grafts and saphenous-vein grafts have been individually underpowered to detect differences in clinical outcomes. We performed a patient-level combined analysis of randomized, controlled trials to compare radial-artery grafts and saphenous-vein grafts for CABG. METHODS: Six trials were identified. The primary outcome was a composite of death, myocardial infarction, or repeat revascularization. The secondary outcome was graft patency on follow-up angiography. Mixed..

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Funding Acknowledgements

Supported by the Department of Cardiothoracic Surgery of Weill Cornell Medicine, the National Institute for Health Research Bristol Biomedical Research Centre (to Dr. Benedetto), and the Bernard S. Goldman Chair in Cardiovascular Surgery (to Dr. Fremes).Dr. Biondi-Zoccai reports receiving consulting fees and lecture fees from Abbott Vascular and lecture fees from Bayer; and Dr. Hare, receiving advisory board fees from Amgen, AstraZeneca, Merck, and Sanofi, lecture fees from Novartis, consulting fees from Pfizer, and grant support from Servier. No other potential conflict of interest relevant to this article was reported.