Journal article

Serological responses to rotavirus NSP2 following administration of RV3-BB human neonatal rotavirus vaccine

Daniel Cowley, Daniel Pavlic, Nada Bogdanovic-Sakran, Karen Boniface, Carl D Kirkwood, Julie E Bines

HUMAN VACCINES & IMMUNOTHERAPEUTICS | TAYLOR & FRANCIS INC | Published : 2018

Abstract

Serum rotavirus IgA responses are an imperfect non-mechanistic correlate of protection, and the lack of an accurate serological marker is a challenge to the development of new rotavirus vaccines. Serological responses to rotavirus NSP2 occur following wild-type infection; however, it is unknown if serological responses to NSP2 occur following administration of rotavirus vaccines. The phase IIa immunogenicity trial of RV3-BB provided an opportunity to investigate the serological responses to NSP2 following vaccination. Healthy, full-term babies (n = 96) were previously recruited as part of a phase IIa safety and immunogenicity trial in Dunedin, New Zealand between January 2012 and April 2014...

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Grants

Awarded by Bill and Melinda Gates Foundation


Awarded by Australian National Health and Medical Research Council


Awarded by New Zealand Health Research Council International Investment Opportunities Fund Trans- Tasman Clinical Trials Collaborative Initiative


Funding Acknowledgements

This study was funded by an investigator driven grant from the Bill and Melinda Gates Foundation (OPP1127967). The Phase IIa clinical trial of RV3-BB was supported by the Australian National Health and Medical Research Council through a project grant (ID491239) and the New Zealand Health Research Council International Investment Opportunities Fund Trans- Tasman Clinical Trials Collaborative Initiative (08_T02). This research was also supported by the Victorian Government's Operational Infrastructure Support Program.