Journal article
Down-regulation of a pro-apoptotic pathway regulated by PCAF/ADA3 in early stage gastric cancer
D Brasacchio, RA Busuttil, T Noori, RW Johnstone, A Boussioutas, JA Trapani
Cell Death and Disease | NATURE PUBLISHING GROUP | Published : 2018
Open access
Abstract
The loss of p300/CBP-associated protein (PCAF) expression is associated with poor clinical outcome in gastric cancer, and a potential bio-marker for invasive and aggressive tumors. However, the mechanism linking loss of PCAF to the onset of gastric cancer has not been identified. Given that PCAF and its binding partner transcriptional adaptor protein 3 (ADA3) were recently shown to regulate the intrinsic (mitochondrial) pathway to apoptosis via epigenetic regulation of phosphofurin acidic cluster sorting proteins 1 and 2 (PACS1, PACS2), we analyzed PCAF, ADA3, and PACS1/2 expression in 99 patient-matched surgical samples ranging from normal gastric mucosa, through pre-malignant chronic gastr..
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Funding Acknowledgements
This study was supported by Program, Fellowship and Project grant support from the National Health and Medical Research Council (NHMRC) of Australia and the Cancer Council Victoria, Australia.