Journal article

LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis

Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Amanda Fisher, Ciaran Hutchinson, Lucia Taraborrelli, Torsten Hartwig, Elodie Lafont, Tobias L Haas, Yutaka Shimizu, Charlotta Boiers, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Michael T Ashworth, Allison Beal Show all

Nature | NATURE PUBLISHING GROUP | Published : 2018


Awarded by Cancer Research UK through the CRUK-UCL Centre

Awarded by Cancer Immunotherapy Accelerator award (CITA)

Awarded by Wellcome Trust Senior Investigator Award

Awarded by ERC Advanced grant

Awarded by Cancer Research UK programme

Awarded by NHMRC

Awarded by Leukemia and Lymphoma Society

Awarded by Swiss National Science Foundation

Funding Acknowledgements

V. Dixit and K. Newton provided Ripk3<SUP>-/-</SUP> mice, S. Hedrick and R. Hakem provided Casp8<SUP>fl/fl</SUP> mice; H. Anderton and U. Nachbur helped with Sharpin<SUP>cpdm</SUP> analysis; P. Levy and staff and L. Lawrence provided technical and histology services. A. Leister and J. Marinis advised on GSK'457A. T. Marafioti and A. Akarsa helped with phosphorylated MLKL detection. A. Annibaldi provided scientific advice and helpful discussions. B.J. Ferguson provided reagents and advice. The flow cytometry, microscopy and imaging core facilities are supported by Cancer Research UK through the CRUK-UCL Centre (515818) and a Cancer Immunotherapy Accelerator award (CITA, 525877). This work was funded by a Wellcome Trust Senior Investigator Award (096831/Z/11/Z), an ERC Advanced grant (294880) and a Cancer Research UK programme grant (A17341) awarded to H.W., NHMRC grants awarded to P.B., A.St., J. S. and H.W. (602516, 1037321, 1043414, 1080321, 1105209, 461221, 1042629, 1057905), the Leukemia and Lymphoma Society (Specialised Center of Research grant 7015) and a postdoctoral fellowship awarded to N.P. by the Swiss National Science Foundation (P300P3_158509).