Journal article
Lipid-lowering pretreatment and outcome following intravenous thrombolysis for acute ischaemic stroke: a post hoc analysis of the enhanced control of hypertension and thrombolysis stroke study trial
JS Minhas, X Wang, H Arima, PM Bath, L Billot, JP Broderick, GA Donnan, JS Kim, PM Lavados, TH Lee, SCO Martins, VV Olavarría, JD Pandian, OM Pontes-Neto, S Ricci, S Sato, VK Sharma, NH Thang, JG Wang, M Woodward Show all
Cerebrovascular Diseases | Published : 2018
DOI: 10.1159/000488911
Abstract
Background: Debate exists as to whether statin pretreatment confers an increased risk of 90-day mortality and symptomatic intracranial haemorrhage (sICH) in acute ischaemic stroke (AIS) patients treated with intravenous thrombolysis. We assessed the effects of undifferentiated lipid-lowering pretreatment on outcomes and interaction with low-dose versus standard-dose alteplase in a post hoc subgroup -analysis of the Enhanced Control of Hypertension and Thrombolysis Stroke Study. Methods: In all, 3,284 thrombolysis-eligible AIS patients (mean age 66.6 years; 38% women), with information on lipid-lowering pretreatment, were randomly assigned to low-dose (0.6 mg/kg) or standard-dose (0.9 mg/kg) ..
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Awarded by Ministerio de Sanidad, Consumo y Bienestar Social
Funding Acknowledgements
The study is supported by grants from the National Health and Medical Research Council (NHMRC) of Australia, the Stroke Association of the United Kingdom, the Ministry of Health and the National Council for Scientific and Technological Development of Brazil (CNPQ: 467322/2014-7, 402388/2013-5), and the Ministry for Health, Welfare and Family Affairs of the Republic of Korea (HI14C1985).