Understanding dengue virus evolution to support epidemic surveillance and counter-measure development
S Pollett, MC Melendrez, Maljkovic Berry, S Duchene, H Salje, DAT Cummings, RG Jarman
INFECTION GENETICS AND EVOLUTION | ELSEVIER | Published : 2018
Dengue virus (DENV) causes a profound burden of morbidity and mortality, and its global burden is rising due to the co-circulation of four divergent DENV serotypes in the ecological context of globalization, travel, climate change, urbanization, and expansion of the geographic range of the Ae.aegypti and Ae.albopictus vectors. Understanding DENV evolution offers valuable opportunities to enhance surveillance and response to DENV epidemics via advances in RNA virus sequencing, bioinformatics, phylogenetic and other computational biology methods. Here we provide a scoping overview of the evolution and molecular epidemiology of DENV and the range of ways that evolutionary analyses can be applie..View full abstract
Awarded by NIH
Awarded by US Department of Defense Global Emerging Infections Surveillance and Response System (DoD-GEIS), a division of the Armed Forces Health Surveillance Branch
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
DATC and HS received support for this work from NIH grant R01AI114703. SD was supported by a McKenzie fellowship from the University of Melbourne. SP was supported by an NRC fellowship from the National Academies. RGJ, SP, MCM and IMB were supported by the US Department of Defense Global Emerging Infections Surveillance and Response System (DoD-GEIS), a division of the Armed Forces Health Surveillance Branch (work unit number: P0082_18_WR). The funders had no role in the writing of this review article.