Journal article

Studying X chromosome inactivation in the single-cell genomic era

Andrew Keniry, Marnie E Blewitt

BIOCHEMICAL SOCIETY TRANSACTIONS | PORTLAND PRESS LTD | Published : 2018

Abstract

Single-cell genomics is set to revolutionise our understanding of how epigenetic silencing works; by studying specific epigenetic marks or chromatin conformations in single cells, it is possible to ask whether they cause transcriptional silencing or are instead a consequence of the silent state. Here, we review what single-cell genomics has revealed about X chromosome inactivation, perhaps the best characterised mammalian epigenetic process, highlighting the novel findings and important differences between mouse and human X inactivation uncovered through these studies. We consider what fundamental questions these techniques are set to answer in coming years and propose that X chromosome inac..

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Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

M.E.B. was supported by a Bellberry-Viertel Senior Medical Research fellowship, and A.K. and M.E.B. were supported by a National Health and Medical Research Council of Australia grant [GNT1140976]. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian National Health and Medical Research Council Research Institute Infrastructure Support Scheme.