Journal article
Human milk oligosaccharides and associations with immune-mediated disease and infection in childhood: A systematic review
AM Doherty, CJ Lodge, SC Dharmage, X Dai, L Bode, AJ Lowe
Frontiers in Pediatrics | FRONTIERS MEDIA SA | Published : 2018
Abstract
Complex sugars found in breastmilk, human milk oligosaccharides (HMOs), may assist in early-life immune programming and prevention against infectious diseases. This study aimed to systematically review the associations between maternal levels of HMOs and development of immune-mediated or infectious diseases in the offspring. PubMed and EMBASE databases were searched (last search on 22 February 2018) according to a predetermined search strategy. Original studies published in English examining the effect of HMOs on immune-mediated and infectious disease were eligible for inclusion. Of 847 identified records, 10 articles from 6 original studies were included, with study quality ranging from low..
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Funding Acknowledgements
AL, SD, and CL are supported by the National Health and Medical Research Council (NHMRC), and CL was supported by Asthma Australia to undertake this work.