Human Milk Oligosaccharides and Associations With Immune-Mediated Disease and Infection in Childhood: A Systematic Review
Alice M Doherty, Caroline J Lodge, Shyamali C Dharmage, Xin Dai, Lars Bode, Adrian J Lowe
FRONTIERS IN PEDIATRICS | FRONTIERS MEDIA SA | Published : 2018
Complex sugars found in breastmilk, human milk oligosaccharides (HMOs), may assist in early-life immune programming and prevention against infectious diseases. This study aimed to systematically review the associations between maternal levels of HMOs and development of immune-mediated or infectious diseases in the offspring. PubMed and EMBASE databases were searched (last search on 22 February 2018) according to a predetermined search strategy. Original studies published in English examining the effect of HMOs on immune-mediated and infectious disease were eligible for inclusion. Of 847 identified records, 10 articles from 6 original studies were included, with study quality ranging from low..View full abstract
AL, SD, and CL are supported by the National Health and Medical Research Council (NHMRC), and CL was supported by Asthma Australia to undertake this work.