The genetic basis of cerebral palsy
Michael C Fahey, Alastair H Maclennan, Doris Kretzschmar, Jozef Gecz, Michael C Kruer
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY | WILEY | Published : 2017
Although prematurity and hypoxic-ischaemic injury are well-recognized contributors to the pathogenesis of cerebral palsy (CP), as many as one-third of children with CP may lack traditional risk factors. For many of these children, a genetic basis to their condition is suspected. Recent findings have implicated copy number variants and mutations in single genes in children with CP. Current studies are limited by relatively small patient numbers, the underlying genetic heterogeneity identified, and the paucity of validation studies that have been performed. However, several genes mapping to intersecting pathways controlling neurodevelopment and neuronal connectivity have been identified. Analo..View full abstract
MCK has received grant support from Retrophin, served as a speaker for the Tourette Association of American, as a consultant for eMedicine and the US HRSA, as an advisory committee member for Lundbeck, and as a grant reviewer for the US Department of Defense. MCF, AHM, DK, and JG have stated that they had no interests which might be perceived as posing a conflict or bias.