Umbilical cord blood cells for treatment of cerebral palsy; timing and treatment options
Courtney A McDonald, Michael C Fahey, Graham Jenkin, Suzanne L Miller
Pediatric Research | NATURE PUBLISHING GROUP | Published : 2018
Cerebral palsy is the most common cause of physical disability in children, and there is no cure. Umbilical cord blood (UCB) cell therapy for the treatment of children with cerebral palsy is currently being assessed in clinical trials. Although there is much interest in the use of UCB stem cells for neuroprotection and neuroregeneration, the mechanisms of action are not fully understood. Further, UCB contains many stem and progenitor cells of interest, and we will point out that individual cell types within UCB may elicit specific effects. UCB is a clinically proven source of hemotopoietic stem cells (HSCs). It also contains mesenchymal stromal cells (MSCs), endothelial progenitor cells (EPC..View full abstract
C.M. is supported by a National Health and Medical Research Council and Cerebral Palsy Alliance Australia Early Career Fellowship. S.L.M. is supported by a Future Fellowship from the Australian Research Council. This work is also supported by Inner Wheel Australia and the Victorian Government's Operational Infrastructure Support Program.