Journal article

Detection and assessment of brain injury in the growth-restricted fetus and neonate

Atul Malhotra, Michael Ditchfield, Michael C Fahey, Margie Castillo-Melendez, Beth J Allison, Graeme R Polglase, Euan M Wallace, Ryan Hodges, Graham Jenkin, Suzanne L Miller

Pediatric Research | NATURE PUBLISHING GROUP | Published : 2017


Fetal growth restriction (FGR) is a common complication of pregnancy and, in severe cases, is associated with elevated rates of perinatal mortality, neonatal morbidity, and poor neurodevelopmental outcomes. The leading cause of FGR is placental insufficiency, with the placenta failing to adequately meet the increasing oxygen and nutritional needs of the growing fetus with advancing gestation. The resultant chronic fetal hypoxia induces a decrease in fetal growth, and a redistribution of blood flow preferentially to the brain. However, this adaptation does not ensure normal brain development. Early detection of brain injury in FGR, allowing for the prediction of short- and long-term neurodeve..

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Funding Acknowledgements

AM is supported by a Royal Australasian College of Physicians Foundation Research Scholarship; GRP is supported by a National Health and Medical Research Council Fellowship; and SM is supported by an Australian Research Council Future Fellowship. We would also wish to acknowledge the Victorian Government's Operational Infrastructure Support program.