Comparison of preterm and term equivalent age MRI for the evaluation of preterm brain injury
A Malhotra, MC Fahey, M Davies-Tuck, F Wong, E Carse, G Whiteley, M Ditchfield
JOURNAL OF PERINATOLOGY | NATURE PUBLISHING GROUP | Published : 2017
OBJECTIVE: To compare information obtained from preterm magnetic resonance imaging (MRI; 31-34 weeks) brain scan to that done at term equivalent age. STUDY DESIGN: Prospective observational study of premature infants with evidence or suspicion of parenchymal brain injury on cranial ultrasound. Brain injury on two scans scored using a scoring system and analyzed. RESULTS: Fourteen infants with a median (range) gestation at birth of 28 (25-29) weeks and birth weight of 1254 (680-1557) grams were studied. There was a strong correlation between the brain injury scores for the two scans (Spearman ρ=0.87, P=0.001) with excellent agreement between two radiologists (interclass correlation coefficien..View full abstract
The study was supported by a Southern Health Senior Medical Staff Association Award and the Victorian Government's Operational Infrastructure Program. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards (HREC approval number 11219B). Informed consent was obtained from all individual participants included in the study.