Antioxidants and other pharmacological treatments for Friedreich ataxia.
Mary Kearney, Richard W Orrell, Michael Fahey, Massimo Pandolfo
Cochrane Database Syst Rev | Published : 2009
BACKGROUND: Friedreich ataxia is a rare inherited, autosomal recessive, neurological disorder characterised initially by unsteadiness in standing and walking, slowly progressing to wheelchair dependency usually in the late teens or early twenties. It is associated with slurred speech, scoliosis, pes cavus and heart abnormalities which may cause premature death in 60 to 80% of people. There is no easily defined clinical or biochemical marker and no known treatment. OBJECTIVES: To examine the efficacy of antioxidants and other pharmacological treatments for Friedreich ataxia. SEARCH STRATEGY: We searched The Cochrane Neuromuscular Disease Group Trials Specialized Register (17 December 2008), T..View full abstract