Journal article
Impact of severe lesion calcification on clinical outcome of patients with stable angina, treated with newer generation permanent polymer-coated drug-eluting stents A patient-level pooled analysis from TWENTE and DUTCH PEERS (TWENTE II)
J Huisman, LC Van Der Heijden, MM Kok, PW Danse, GAJ Jessurun, MG Stoel, KG Van Houwelingen, MM Löwik, RWM Hautvast, MJ Ijzerman, CJ Doggen, C Von Birgelen
American Heart Journal | MOSBY-ELSEVIER | Published : 2016
Abstract
Background The outcome of percutaneous coronary intervention with newer generation permanent polymer-coated drug-eluting stents (DES) in patients with severely calcified lesions is greatly unknown. We assessed the impact of severe lesion calcification on clinical outcome in patients with stable angina who underwent percutaneous coronary intervention with newer generation DES. Methods TWENTE and DUTCH PEERS randomized trials enrolled 1423 patients with stable angina, who were categorized into patients with versus without severe target lesion calcification. A patient-level pooled analysis assessed clinical outcome, including target vessel failure (TVF), a composite of cardiac death, target ves..
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Funding Acknowledgements
This study was performed without external funding. The TWENTE and DUTCH PEERS (TWENTE II) randomized trials were supported by equal unrestricted grants from Abbott Vascular and Medtronic, and from Boston Scientific and Medtronic, respectively. RCT# 01066650 and NCT01331707Submitted November 20, 2015; accepted February 9, 2016.