Journal article
Cord blood CD8 T cells have a natural propensity to express IL-4 in a fatty acid metabolism and caspase activation-dependent manner
Y Zhang, J Maksimovic, B Huang, DP De Souza, G Naselli, H Chen, L Zhang, K Weng, H Liang, Y Xu, JM Wentworth, ND Huntington, A Oshlack, S Gong, A Kallies, P Vuillermin, M Yang, LC Harrison
Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2018
Abstract
How T cells differentiate in the neonate may critically determine the ability of the infant to cope with infections, respond to vaccines and avert allergies. Previously, we found that naïve cord blood CD4+ T cells differentiated toward an IL-4-expressing phenotype when activated in the presence of TGF-β and monocyte-derived inflammatory cytokines, the latter are more highly secreted by infants who developed food allergy. Here, we show that in the absence of IL-2 or IL-12, naïve cord blood CD8+ T cells have a natural propensity to differentiate into IL-4-producing non-classic TC2 cells when they are activated alone, or in the presence of TGF-β and/or inflammatory cytokines. Mechanistically, n..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by an Australian National Health and Medical Research Council (NHMRC) Program Grant 1037321 (LH), and Project Grants 1029927 and 1082307 (PV), a Juvenile Diabetes Research Foundation Project Grant 17-2013-547 (LH and YZ), Walter and Eliza Hall Institute Catalyst Fund grant 45941 (YZ), National Natural Science Foundation of China 31770978 and 91742109 (YZ), and Guangzhou Women and Children's Medical Center Startup Fund 5001-3001032 (YZ). It was made possible through Victorian State Government Operational Infrastructure Support and Australian National Health and Medical Research Council Research Institute Infrastructure Support Scheme. LH holds an NHMRC Senior Principal Research Fellowship 1080887. We thank the BIS and GWCMC participants.