Journal article
Impact of lesion load thresholds on Alberta stroke program early computed tomographic score in diffusion-weighted imaging
J Schröder, B Cheng, C Malherbe, M Ebinger, M Köhrmann, O Wu, DW Kang, DS Liebeskind, T Tourdias, OC Singer, B Campbell, M Luby, S Warach, J Fiehler, A Kemmling, JB Fiebach, C Gerloff, G Albers, S Davis, G Donnan Show all
Frontiers in Neurology | FRONTIERS MEDIA SA | Published : 2018
Open access
Abstract
Background and aims: Assessment of ischemic lesions on computed tomography or MRI diffusion-weighted imaging (DWI) using the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is widely used to guide acute stroke treatment. However, it has never been defined how many voxels need to be affected to label a DWI-ASPECTS region ischemic. We aimed to assess the effect of various lesion load thresholds on DWI-ASPECTS and compare this automated analysis with visual rating. Materials and methods: We analyzed overlap of individual DWI lesions of 315 patients from the previously published predictive value of fluid-attenuated inversion recovery study with a probabilistic ASPECTS template d..
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Awarded by European Commission
Funding Acknowledgements
PRE-FLAIR received funding from the Else Kroner-Fresenius-Stiftung (2009_A36). Funding was provided for central data collection and analysis; there was no funding for inclusion of patients. We thank the EPITHET (Echoplanar Imaging Thrombolysis Evaluation Trial) investigators, the University of California, Los Angeles Stroke investigators, all co-investigators of VIRAGE, and all our colleagues from the Departments of Neurology and Neuroradiology, and medical and technical staff in the participating centers for their support. In Berlin, data were collected within the 1,000+ study, which has received funding from the Federal Ministry of Education and Research via the grant Center for Stroke Research Berlin (01 EO 0801). PRE-FLAIR was further supported by the European Union Seventh Framework Program grant agreement No 202213 and No 223153 (European Stroke Network), the Volkswagen Foundation, and the Deutsche Forschungsgemeinschaft. EPITHET was funded by the National Health and Medical Research Council (Australia), the National Stroke Foundation (Australia), and the Heart Foundation of Australia. VIRAGE is supported by French national grant PHRC. This work was supported by Seton/UT Southwestern Clinical Research Institute of Austin, Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Austin, TX, USA, and the National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, MD, USA.