Journal article
Adar3 is involved in learning and memory in mice
D Mladenova, G Barry, LM Konen, SS Pineda, B Guennewig, L Avesson, R Zinn, N Schonrock, M Bitar, N Jonkhout, L Crumlish, DC Kaczorowski, A Gong, M Pinese, GR Franco, CR Walkley, B Vissel, JS Mattick
Frontiers in Neuroscience | FRONTIERS MEDIA SA | Published : 2018
Abstract
The amount of regulatory RNA encoded in the genome and the extent of RNA editing by the post-transcriptional deamination of adenosine to inosine (A-I) have increased with developmental complexity and may be an important factor in the cognitive evolution of animals. The newest member of the A-I editing family of ADAR proteins, the vertebrate-specific ADAR3, is highly expressed in the brain, but its functional significance is unknown. In vitro studies have suggested that ADAR3 acts as a negative regulator of A-I RNA editing but the scope and underlying mechanisms are also unknown. Meta-analysis of published data indicates that mouse Adar3 expression is highest in the hippocampus, thalamus, amy..
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Awarded by University of California, Davis
Funding Acknowledgements
This work was funded by the Australian Research Council, Discovery Project DP120100729; JM was an NHMRC Australia Fellow (631668) during much of this work; DM is a recipient of the Science and Industry Endowment Fund John Stocker Postdoctoral Fellowship PF13-040; CW was a Leukemia Foundation Phillip Desbrow Senior Research Fellow and LA was recipient of the Swedish Research Council grant N: 350-2012-375. We acknowledge funding from the NIH through grants awarded to Velocigene at Regeneron Inc (U01HG004085) and the CSD Consortium (U01HG004080). CSD funded the generation of gene-targeted ES cells for 8500 genes in the KOMP Program and archived and distributed by the KOMP Repository at UC Davis and CHORI (U42RR024244; for more information or to obtain KOMP products go to www.komp.org or email service@komp.org).