Journal article

Role of vitamin D in multiple sclerosis: implications for disease management

Ingrid AF van der Mei, Steve Simpson, Stephanie Knippenberg, Tania Winzenberg, Bruce V Taylor

Neurodegenerative Disease Management | Future Medicine Ltd | Published : 2011

Abstract

SUMMARY This review discusses the evidence on the role of vitamin D in multiple sclerosis (MS) and whether vitamin D supplementation is effective for the management of MS. People with MS are at high risk of vitamin D deficiency, osteoporosis and fractures. Observational data suggest that higher vitamin D levels are associated with lower relapse risk and there is promising evidence on its effect on MRI measures, disability progression, mental health and fatigue. However, there is currently insufficient randomized controlled trial evidence to recommend vitamin D supplementation with the aim to improve those outcomes. There is sufficient evidence to justify assessing and correcting vitamin D an..

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