Journal article

Treatment Intensity Differences After Early-Stage Breast Cancer (ESBC) Diagnosis Depending on Participation in a Screening Program

Kenneth Elder, Carolyn Nickson, Melinda Pattanasri, Samuel Cooke, Dorothy Machalek, Allison Rose, Arlene Mou, John Paxton Collins, Allan Park, Richard De Boer, Claire Phillips, Vicki Pridmore, Helen Farrugia, G Bruce Mann



BACKGROUND: While population mammographic screening identifies early-stage breast cancers (ESBCs; ductal carcinoma in situ [DCIS] and invasive disease stages 1-3A), commentaries suggest that harms from overdiagnosis and overtreatment may outweigh the benefits. Apparent benefits to patients with screen-detected cancers may be due to selection bias from exclusion of interval cancers (ICs). Treatment intensity is rarely discussed, with an assumption that all ESBCs are treated similarly. We hypothesized that women diagnosed while in a screening program would receive less-intense treatment than those never or not recently screened (NRS). METHODS: This was a retrospective analysis of all women age..

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Funding Acknowledgements

This project is partly funded through the Cancer Australia Priority-driven Collaborative Cancer Research Scheme (Nickson C, Canfell K, Barandregt J, Petrie D, Mann B, Brennan P. Maximising benefits and minimising harms in the BreastScreen program: a population health economics modelling approach. 2014-2016) and by research funds of the Royal Melbourne Hospital/Royal Women's Hospital Breast Service.