Effect of sildenafil citrate on circulating levels of sFlt-1 in preeclampsia

FC Brownfoot; S Tong; NJ Hannan; P Cannon; V Nguyen; TJ Kaitu'u-Lino

Journal article

Effect of sildenafil citrate on circulating levels of sFlt-1 in preeclampsia

FC Brownfoot, S Tong, NJ Hannan, P Cannon, V Nguyen, TJ Kaitu'u-Lino

Pregnancy Hypertension | ELSEVIER SCI LTD | Published : 2018

DOI: 10.1016/j.preghy.2018.04.011

Abstract

Objectives: To examine the effect of sildenafil on level of antiangiogenic proteins of preeclampsia. Firstly to examine the effect of sildenafil on serum biomarkers in a patient with preterm preeclampsia. Secondly, to examine the effect of sildenafil on sFlt-1 and soluble endoglin secretion from primary trophoblasts and placental explants. Study design: The clinical team administered 50 mg tds sildenafil to a 26-year-old primigravid woman with severe preeclampsia at the threshold of viability (24 3/7 weeks gestation) and we collected bloods to examine the effect of slidenafil on antiangiogenic factors sFlt-1 and soluble endoglin (sENG), pro-angiogenic factor PlGF and vascular cell adhesion m..

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University of Melbourne Researchers

Fiona Brownfoot Author

Stephen Tong Author

Natalie Hannan Author

Ping Cannon Author

Grants

Funding Acknowledgements

FCB was supported by a Mercy Perinatal Fellowship. TKL (#1062418) and ST (#1050765) NJH by The University of Melbourne C R Roper Fellowship. The funders had no role in study design, data collection, analysis, decision to publish or the preparation of the manuscript.