Characterization of Blimp-1 function in effector regulatory T cells

E Cretney; PS Leung; S Trezise; DM Newman; LC Rankin; CE Teh; TL Putoczki; DH Gray; GT Belz; LA Mielke; S Dias; SL Nutt

Journal article

Characterization of Blimp-1 function in effector regulatory T cells

E Cretney, PS Leung, S Trezise, DM Newman, LC Rankin, CE Teh, TL Putoczki, DH Gray, GT Belz, LA Mielke, S Dias, SL Nutt

Journal of Autoimmunity | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2018

DOI: 10.1016/j.jaut.2018.04.003

Abstract

Regulatory T (T reg ) cells maintain immunological tolerance in steady-state and after immune challenge. Activated T reg cells can undergo further differentiation into an effector state that highly express genes critical for T reg cell function, including ICOS, TIGIT and IL-10, although how this process is controlled is poorly understood. Effector T reg cells also specifically express the transcriptional regulator Blimp-1 whose expression overlaps with many of the canonical markers associated with effector T reg cells, although not all ICOS + TIGIT + T reg cells express Blimp-1 or IL-10. In this study, we addressed the role of Blimp-1 in effector T reg cell function. Mice lacking Blimp-1 spe..

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University of Melbourne Researchers

Erika Cretney Author

Dane Newman Author

Charis En-Yi Teh Author

Tracy Putoczki Author

Grants

Awarded by European Commission

Funding Acknowledgements

We thank Jamie Leahy and Liana Mackiewicz for technical support and the WEHI Flow Cytometry Laboratory staff for assistance in cell sorting. We thank Alexander Rudensky for mice. Research was supported by the National Health and Medical Research Council of Australia (program grant #1054925 to SLN and GTB, project grant #1047313 to EC, project grant #1078763 to DHDG and fellowships to EC, SLN, CET, DHDG and GTB). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIIS.