Journal article
Long-term Impact of Oral Azithromycin Taken by Gambian Women during Labor on Prevalence and Antibiotic Susceptibility of Streptococcus pneumoniae and Staphylococcus aureus in Their Infants: Follow-up of a Randomized Clinical Trial
A Bojang, B Camara, I Jagne Cox, C Oluwalana, K Lette, E Usuf, C Bottomley, BP Howden, U D'Alessandro, A Roca
Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2018
DOI: 10.1093/cid/ciy254
Open access
Abstract
Background Oral azithromycin given to women in labor decreases maternal and neonatal bacterial carriage but increases azithromycin-resistant bacteria during at least 4 weeks following the intervention. We assessed the prevalence of bacterial carriage and azithromycin resistance 12 months after treatment among study infants. Methods Nasopharyngeal swabs (NPSs) were collected between November 2014 and May 2015 from children aged 11-13 months whose mothers had received azithromycin or placebo during labor. Streptococcus pneumoniae and Staphylococcus aureus were isolated using conventional microbiological methods. Antibiotic susceptibility was determined by disk diffusion and confirmed by Etest ..
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Awarded by Medical Research Council
Funding Acknowledgements
This work was supported by the Medical Research Council (MRC) Unit The Gambia PhD fellowship. The main trial was jointly funded by the UK MRC and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement (reference number MR/J010391/1) and is also part of the EDCTP2 program supported by the European Union.