Journal article

Protein aggregation in cell biology: An aggregomics perspective of health and disease

Dezerae Cox, Candice Raeburn, Xiaojing Sui, Danny M Hatters

Seminars in Cell & Developmental Biology | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2020

Abstract

Maintaining protein homeostasis (proteostasis) is essential for cellular health and is governed by a network of quality control machinery comprising over 800 genes. When proteostasis becomes imbalanced, proteins can abnormally aggregate or become mislocalized. Inappropriate protein aggregation and proteostasis imbalance are two of the central pathological features of common neurodegenerative diseases including Alzheimer, Parkinson, Huntington, and motor neuron diseases. How aggregation contributes to the pathogenic mechanisms of disease remains incompletely understood. Here, we integrate some of the key and emerging ideas as to how protein aggregation relates to imbalanced proteostasis with ..

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Grants

Awarded by National Health and Medical Research Council


Awarded by Australian Research Council


Awarded by Human Frontiers Science Program Grant


Funding Acknowledgements

This work was supported by grants to D.M.H (National Health and Medical Research Council grant APP1102059, Australian Research Council (DP170103093) and Human Frontiers Science Program Grant RGP0022/2017).