Journal article

Clinical studies of the effectiveness and safety of antivenoms

David J Williams, Abdulrazaq G Habib, David A Warrell

TOXICON | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2018

Abstract

In the 1890s, hyperimmune sera proved effective in animals against challenge by the snake venom against which they had been raised. They were first used, apparently successfully, in a human patient in about 1895. Since then, antivenoms have become accepted as the only reliable specific treatment for snake-bite envenoming. Despite decades of accumulated clinical experience and a number of published randomized comparative and observational studies, the clinical effectiveness and safety of some antivenoms remain open to question, due to a lack of robust randomized controlled trial data. Antivenoms in some poorly regulated markets may have high rates of potentially fatal adverse effects and thei..

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University of Melbourne Researchers